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目的探讨血清谷胱甘肽S-转移酶与消化道肿瘤的关系,筛选肿瘤检测的血清标志物。方法采用放免法测定消化道肿瘤患者(胃癌16例,食管癌4例,肝癌8例,结肠癌8例)血浆谷胱甘肽S-转移酶(GST-p)的含量和活性改变。结果 GST-p在胃癌、食管癌、肝癌及肠癌等病时升高(27.5±24.5μg/L),明显高于正常人组(7.1±2.3μg/L);GST-p在癌前病变组高于正常人组(P<0.01);GST-p含量与肿瘤的分化程度呈正相关。结论 GST-p不仅是机体损伤解毒的酶,它与肿瘤的发生、发展有关,是肿瘤早期诊断有价值的标志酶。
Objective To investigate the relationship between serum glutathione S-transferase and digestive tract tumors, and to screen serum markers for tumor detection. Methods The content and activity of plasma glutathione S-transferase (GST-p) in patients with digestive tract tumors (16 cases of gastric cancer, 4 cases of esophageal cancer, 8 cases of liver cancer, and 8 cases of colon cancer) were determined by radioimmunoassay. Results GST-p was elevated in gastric cancer, esophageal cancer, liver cancer, and colorectal cancer (27.5±24.5 μg/L), which was significantly higher than that in normal group (7.1±2.3 μg/L); GST-p was in precancerous lesions. The group was higher than the normal group (P<0.01); GST-p content was positively correlated with the degree of tumor differentiation. Conclusion GST-p is not only an enzyme that detoxifies the body but it is related to the occurrence and development of tumors. It is a valuable marker enzyme for early diagnosis of tumors.