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近年来，基质金属蛋白酶（ＭＭＰｓ）和金属蛋白酶组织抑制因子（ＴＩＭＰｓ）在肾脏病尤其是肾小球硬化和肾间质纤维化中的作用已受到人们的关注。ＭＭＰｓ是一类以锌离子为活性中心辅基的蛋白酶，已发现至少１６种，其中ＭＭＰ－１、－２、－３、－７、－９、－１０、－１１能在肾组织表达。ＴＩＭＰｓ能特异性地与ＭＭＰｓ活性中心的锌离子结合而抑制ＭＭＰｓ活性，已发现４种ＴＩＭＰｓ，均能在肾脏表达。本文综述近年来国外关于增殖性肾炎、膜性肾病、糖尿病肾病、肾小球硬化、肾间质纤维化、多囊肾等肾脏疾病或动物模型ＭＭＰｓ／ＴＩＭＰｓ表达及相互关系的研究成果、并作有关评论
In recent years, the role of matrix metalloproteinases (MMPs) and metalloproteinase tissue inhibitors (TIMPs) in renal disease, especially in glomerulosclerosis and renal interstitial fibrosis has received much attention. MMPs are a class of proteases with zinc ions as the active center. At least 16 MMPs have been found, among which MMP-1, -2, -3, -7, -9, -10 and -11 can be expressed in renal tissues. TIMPs specifically bind to the zinc ions in the active center of MMPs and inhibit the activity of MMPs. All four TIMPs have been found to be expressed in the kidney. This review summarizes the recent research results on the expression of MMPs / TIMPs and their relationships in proliferative nephritis, membranous nephropathy, diabetic nephropathy, glomerulosclerosis, renal interstitial fibrosis, polycystic kidney disease and other animal models or animal models Related comments