论文部分内容阅读
采用酰氯法合成了3种不同分子量的高分子表面活性剂端甲基聚乙二醇胆甾醇酯(mPEG-chol),并用表面张力法测得其临界胶束浓度(CMC)值。结果表明,随着PEG链长的增加,其CMC值逐渐增大。同时,利用LB膜天平研究了3种mPEG-chol在空气/水界面上单分子膜的π-A等温曲线及其与磷脂单分子膜的相互作用。结果表明,PEG的链长不仅决定了胆甾醇酯在空气/水界面上的表面性质,还影响了mPEG-chol与卵磷脂分子的相互作用。PEG的链越长,与磷脂分子间的作用力越强;mPEG-chol以胆甾基团为锚与磷脂分子发生作用,较长的PEG链反而影响了胆甾基团在磷脂单分子膜中的吸附。
Three kinds of polymers with different molecular weights were synthesized by acid chloride method. The mPEG-chol was measured by surface tension method and its critical micelle concentration (CMC) was measured. The results showed that with the increase of PEG chain length, the CMC value gradually increased. At the same time, π-A isotherm curve of monolayer of mPEG-chol at air / water interface and its interaction with phospholipid monolayer were studied by LB film balance. The results show that the chain length of PEG not only determines the surface properties of cholesterol esters at the air / water interface but also affects the interaction of mPEG-chol with lecithin molecules. The longer the PEG chain, the stronger the interaction with the phospholipid molecules; the mPEG-chol takes the cholesteryl anchor as an anchor to the phospholipid molecule, and the longer PEG chain adversely affects the cholesteryl group in the phospholipid monolayer Adsorption.