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作者提出原发性痛经与前列腺素(主要是前列腺素F)有关。子宫前列腺素来自子宫内膜。而其受体主要在子宫肌层。前列腺素对人子宫肌的体外效应与剂量有关,并取决于月经周期的阶段。前列腺素E使子宫肌弛张,而前列腺素F_(2α)却增加子宫肌收缩的频率和幅度,尤其是对经前子宫肌效应最大。正常未孕妇女应用前列腺素F_(2α)能产生下腹部疼痛、子宫静止时的张力升高并增加收缩的频率和幅度。子宫肌纤维收缩和舒张周期可能是受ATP和游离钙离子二个因素控制。细胞内游离钙的数量取决于①通过细胞膜的钙离子净得的流入量。②钙在
The authors suggest that primary dysmenorrhea is associated with prostaglandins (mainly prostaglandin F). Uterine prostaglandins from the endometrium. The receptor is mainly in the myometrium. The in vitro effect of prostaglandins on human uterine muscle is dose dependent and depends on the stage of the menstrual cycle. Prostaglandin E relaxes the uterine muscles, whereas prostaglandin F_ (2α) increases the frequency and amplitude of uterine muscle contractions, especially in premenopausal uterine muscles. Prostaglandin F_ (2α) can be produced by normal pregnant women with lower abdominal pain, increased tension when resting in the uterus, and increased frequency and amplitude of contractions. Uterine muscle fiber contraction and diastolic cycle may be controlled by two factors of ATP and free calcium. The amount of intracellular free calcium depends on the influx of calcium ions through the cell membrane. ② calcium in