论文部分内容阅读
以胆固醇(Ch)喂饲家兔进行动脉粥样硬化(AS)造型,通过测定血浆脂质、脂质过氧化物、前列腺素水平和血小板功能以及主动脉组织生化和组织学分析,系统观察了硝苯吡啶(N)对实验性AS病变消退的影响。结果显示:N能显著降低总Ch、低密度脂蛋白Ch、载脂蛋白B(ApoB)水平,升高高密度脂蛋白Ch(HDL—Ch)、HDL_2—Ch水平;抑制脂质过氧化,降低血浆丙二醛水平;升高血浆前列环素水平,降低血栓素A_2水平,抑制血小板聚集和释放功能;减少主动脉组织Ch,ApoB和钙的沉积;减少主动脉粥样斑块面积及斑块厚度和减轻粥样病变程度。结果表明,N能促进AS病变的消退。
Cholesterol (Ch) fed rabbits for atherosclerosis (AS) modeling, by measuring the plasma lipid, lipid peroxidation, prostaglandin levels and platelet function and aortic biochemical and histological analysis, the system observed Effect of nifedipine on regression of experimental AS. The results showed that: N can significantly reduce the levels of total cholesterol, low density lipoprotein Ch, apolipoprotein B (ApoB), high density lipoprotein Ch (HDL-Ch) and HDL 2-Ch; inhibit lipid peroxidation and decrease Plasma malondialdehyde levels; increased plasma prostacyclin levels, lower thromboxane A 2 levels, inhibition of platelet aggregation and release function; reduce the aortic tissue Ch, ApoB and calcium deposition; reduce the area of atherosclerotic plaque and plaque Thickness and reduce the degree of atherosclerosis. The results show that N can promote the regression of AS lesions.