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目的 研究 p16、p5 3及nm2 3在喉癌中的表达及其与临床的相关性。 方法 应用免疫组化的方法对 42例喉鳞癌样本进行检测。结果 在喉鳞癌中 p16蛋白表达的阳性率为 47.6 2 % ,p5 3的阳性率为 5 4.76 % ,nm2 3的阳性率为 5 2 .38% ;中、低分化的鳞癌 (Ⅱ～Ⅲ级 )组 p16阳性率低于高分化的鳞癌 (Ⅰ级 )组 (P <0 .0 5 ) ,有淋巴结转移组 p16的表达阳性率低于无淋巴结转移组 (P <0 .0 5 ) ;p5 3在临床Ⅰ期组的阳性率明显高于临床Ⅱ～Ⅳ期组 (P <0 .0 5 ) ;nm2 3在临床Ⅱ～Ⅳ期组的阳性率明显高于Ⅰ期组 (P <0 .0 5 ) .结论 p16蛋白表达与喉癌的细胞分化程度、颈淋巴结转移有关 ,与临床分期、临床分型无关 ;p5 3和nm2 3的表达与临床分期有关 ,与临床分型、细胞分化程度、颈淋巴结转移无关
Objective To study the expression of p16, p5 3 and nm23 in laryngeal carcinoma and its clinical relevance. Methods 42 cases of laryngeal squamous cell carcinoma were detected by immunohistochemistry. Results The positive rate of p16 protein in laryngeal squamous cell carcinoma was 47.6%, the positive rate of p5 3 was 5. 4.76%, and the positive rate of nm23 was 52.38%. The positive rate of p16 protein in moderate and poorly differentiated squamous cell carcinoma (Ⅱ ~ Ⅲ (P <0.05). The positive rate of p16 in lymph node metastasis group was lower than that in non-lymph node metastasis group (P <0.05) ; The positive rate of p5 3 in clinical stage Ⅰ group was significantly higher than that in clinical stage Ⅱ ~ Ⅳ group (P0.05); The positive rate of nm23 in stage Ⅱ ~ Ⅳ group was significantly higher than that in stage Ⅰ group (P < 0 .0 5) .Conclusion The expression of p16 protein is related to the degree of cell differentiation and cervical lymph node metastasis in laryngeal carcinoma, but not with the clinical stage and clinical type. The expression of p5 3 and nm23 is correlated with clinical stage, Differentiation, cervical lymph node metastasis has nothing to do