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目的探讨副伤寒患者血清腺苷脱氨酶(ADA)值改变的临床价值。方法72例副伤寒患者在初期(1～2周)(副伤寒A组)和经治疗症状消失后(副伤寒B组)采用连续监测法检测血清ADA值。以30例正常健康者(健康组)和40例非伤寒发热患者(非伤寒组)为对照。结果副伤寒A组、副伤寒B组、健康组、非伤寒发热组ADA值分别为(46.0±16.6)U/L、(15.2±4.2)U/L、(13.6±5.1)U/L、(15.1±5.4)U/L。副伤寒A组ADA值显著高于健康组和非伤寒组、副伤寒B组(P<0.001);副伤寒B组与健康组比较差异无显著意义(P>0.05)。结论ADA的测定对副伤寒的早期诊断及与非伤寒发热的鉴别诊断、疗效评价具有较高的临床价值。
Objective To investigate the clinical value of serum adenosine deaminase (ADA) in patients with paratyphoid fever. Methods 72 cases of paratyphoid fever patients in the early (1 to 2 weeks) (paratyphoid A group) and after the treatment of symptoms disappeared (paratyphoid B group) using continuous monitoring of serum ADA value. Thirty healthy controls (healthy group) and 40 non-typhoid fever patients (non-typhoid fever group) were used as controls. Results The ADA of paratyphoid A group, paratyphoid B group, healthy group and non-typhoid fever group were (46.0 ± 16.6) U / L, (15.2 ± 4.2) U / L and 15.1 ± 5.4) U / L. Paratyphoid A group ADA value was significantly higher than the healthy group and non-typhoid group, paratyphoid B group (P <0.001); paratyphoid B group and healthy group no significant difference (P> 0.05). Conclusion The determination of ADA has a high clinical value in the early diagnosis of paratyphoid fever and in the differential diagnosis and curative effect evaluation of non-typhoid fever.