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[目的]探讨川崎病患儿急性期凝血功能、D-二聚体的水平与冠状动脉病变(CAL)的关系.[方法]在本院儿科住院治疗的川崎病患儿 194例作为观察组,根据观察组的心脏超声心动图检查结果,分为42例CAL组和 152 例CAL(NCAL组),并同时设置健康对照组 60例.检测所有研究对象的凝血功能,包含凝血酶时间(TT),部分凝血酶原活化时间(APTT),纤维蛋白原定量(FIB)值,以及D-二聚体(D-dimer)水平,对结果进行统计学分析.[结果]川崎病CAL组及 NCAL组的 APTT、TT均比对照组缩短,而 FIB、D-dimer均高于对照组,且差异有显著性(P ＜0.05).其中CAL组与 NCAL组的 TT及 D-dimer水平相比较差异有显著性(P ＜0.05),Logistic回归分析提示TT是CAL的独立影响因素(P ＜0.05),川崎病患儿TT每增加1 s,其发生CAL的风险增加0.838倍.TT诊断CAL的 ROC曲线面积为0.608.[结论]川崎病患儿急性期处于高凝状态,TT是影响CAL较为敏感的独立因素,同时可推测CAL与血管炎症活动有关.“,”[Objective]To investigate the relationship among coagulation function,D-dimer level and coro-nary artery lesions in children with Kawasaki Disease.[Methods]A total of 194 cases with Kawasaki disease children who were diagnosed in the department of pediatrics in our hospital were collected in the study.Ac-cording to the results of heart echocardiography for coronary artery lesions,patients were divided into the cor-onary artery lesions group (CAL,n＝42)and the no-coronary artery lesions group (NCAL,n＝152).At the same time 60 healthy volunteers were formed the control group..Blood coagulation function was tested in all subjects,including thrombin time (TT),partial prothrombin activation time (APTT),fibrinogen (FIB) quantitative values,and D-dimer level.The laboratory results were statistically analyzed.[Results]APTT and TT in both CAL and NCAL groups of Kawasaki disease were shorter than in the control group,while FIB and D-dimer were higher than the control group.The difference was statistically significant (P ＜0.05). There was a significant difference in the TT and D-dimer levels between the CAL group and the NCAL group (P ＜0.05).Logistic regression analysis indicated that TT was an independent influencing factor of coronary artery lesions (P ＜0.05).For every one second increase in TT of Kawasaki disease,the risk of coronary ar-tery lesions increased by 0.838-fold.The ROC curve area (AUCROC)for TT to diagnose coronary artery le-sions of was 0.608.[Conclusion]Children with Kawasaki disease are hypercoagulable in the acute stage.Coag-ulation function TT is an independent and sensitive factor to indicate CAL.At the same time,it can also be speculated that coronary artery lesions is associated with vascular inflammation activity.