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随着代谢性疾病发病率不断升高,子宫内膜癌的发病率不断增长,发病年龄趋于年轻化。前期研究发现,二甲双胍在多种生殖道恶性肿瘤的预防和治疗中发挥着重要作用。流行病学显示,二甲双胍可降低糖尿病患者子宫内膜癌的发病风险,提高子宫内膜癌患者的总生存率和无瘤生存期。本文就二甲双胍在子宫内膜癌预防和治疗方面的研究进展做一综述。
With the rising incidence of metabolic diseases, the incidence of endometrial cancer continues to grow, the age of onset tends to be younger. Previous studies found that metformin plays a major role in the prevention and treatment of multiple genital malignancies. Epidemiology shows that metformin can reduce the risk of endometrial cancer in diabetic patients and improve the overall survival and tumor-free survival of patients with endometrial cancer. This article reviews the progress of metformin in the prevention and treatment of endometrial cancer.