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目的:探讨2型糖尿病(DR)视网膜病变患者血同型半胱氨酸及C反应蛋白的变化及这种变化与发病的相关性。方法:选择已经明确诊断的2型糖尿病患者合并视网膜病变组56例,背景期DR组68例,增殖期66例,同时选择健康对照组80例,血同型半胱氨酸采用酶法,C-反应蛋白采用增强免疫比浊法进行检测,双变量相关分析采用直线相关分析。结果:各组患者血同型半胱氨酸及C-反应蛋白均明显高于对照组,各组间差异显著,随着病程进展,两项指标均升高明显,且呈正相关。结论:血同型半胱氨酸及C反应蛋白在2型糖尿病视网膜病变患者血液中含量随病情加重逐渐升高,因此推测血同型半胱氨酸可能是视网膜病变发生及发展的因素之一,而C反应蛋白可能是糖尿病视网膜病变早期的一个较早检测指标。因此对2型糖尿病患者血同型半胱氨酸及C反应蛋白升高时及时干预治疗预防糖尿病视网膜病变的发生及延缓病程.
Objective: To investigate the changes of plasma homocysteine and C-reactive protein in patients with type 2 diabetic (DR) retinopathy and its relationship with the pathogenesis. Methods: Sixty-six patients with type 2 diabetes mellitus complicated with retinopathy, 68 patients with DR in the background, 66 patients in proliferative phase and 80 healthy controls were enrolled. Blood homocysteine was detected by enzyme-linked immunosorbent assay (ELISA), C- Response protein was detected by enhanced immune turbidimetric method, bivariate correlation analysis using linear correlation analysis. Results: The levels of plasma homocysteine and C-reactive protein in each group were significantly higher than those in the control group. There were significant differences among the groups. As the course of the disease progressed, both indexes increased significantly and positively. Conclusion: Blood homocysteine and C-reactive protein levels in patients with type 2 diabetic retinopathy increased with the severity of the disease, speculated that blood homocysteine may be the occurrence and development of retinopathy, one of the factors, and C-reactive protein may be an early detection of diabetic retinopathy early detection. Therefore, patients with type 2 diabetes, blood homocysteine and C-reactive protein increased timely intervention to prevent the occurrence of diabetic retinopathy and delay the course.