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目的 :检测胎盘型谷胱甘肽S -转移酶 (GST -π)在喉鳞状细胞癌、喉乳头状瘤、声带息肉的表达及意义。方法 :病理诊断确诊的喉鳞状细胞癌标本 3 4例 ,喉乳头状瘤 3 1例 ,声带息肉 3 8例 ,用免疫胶体金方法检测GST -π在喉肿瘤组织的表达。结果 :3 4例喉鳞状细胞癌组织GST -π表达 10 0 %阳性 ,其中有 3例化疗后表达强度增强 ;3 1例喉乳头状瘤组织 12 9%弱阳性表达 ;3 8例声带息肉全部为阴性。结论 :GST -π对喉部良、恶性肿瘤的检测及化疗耐药性的产生方面有重要意义。
Objective: To detect the expression and significance of placental glutathione S - transferase (GST-π) in laryngeal squamous cell carcinoma, laryngeal papilloma and vocal cord polyps. Methods: 34 cases of laryngeal squamous cell carcinoma, 31 cases of laryngeal papilloma and 38 cases of vocal cord polyp were diagnosed by pathology. The expression of GST-π in laryngeal neoplasm was detected by immunogold method. Results: The expression of GST-π in 104 laryngeal squamous cell carcinomas was 100% positive, of which 3 cases were enhanced after chemotherapy. The positive expression of 12 9% in 31 laryngeal papilloma was weakly positive and 38 cases of vocal cord polyps All negative. Conclusion: GST-π is of great significance in the detection of benign and malignant tumors of the larynx and the generation of chemoresistance.