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本文报告1例乙型肝炎疫苗全程接种后2年出现严重急性乙型肝炎病毒(HBV)感染病例.该病例26岁,男性,出现黄疸2天.检查时发现有重度黄疸,伴肝肿大.该患者为同性恋者,但人类免疫缺陷症病毒(HIV)阴性.2年前全程接种乙型肝炎疫苗,三角肌注射1ml,6周后接种第2针,6个月后接种第3针.接种前血清学检查无HBV感染的证据.实验室检查发现,肝功能严重受损,血清胆红素170μmol/L,碱性磷酸酶169IU/L,丙氨酸转氨酶4421IU/L,天冬氨酸转氨酶1825IU/L,γ谷氨酰转肽酶275IU/L.病毒学检测表明,
This article reports a case of severe acute hepatitis B virus (HBV) infection in 2 cases of hepatitis B vaccine two years after inoculation, the case of 26-year-old male with jaundice 2 days.It was found to have severe jaundice and hepatomegaly on examination. The patient was homosexual, but HIV-negative. Hepatitis B vaccine was inoculated 2 years ago, deltoid injections were 1 ml, 2 weeks after 6 weeks, and 3 after 6 months. Pre-serological tests showed no evidence of HBV infection. Laboratory tests revealed severe impairment of liver function with serum bilirubin 170 μmol / L, alkaline phosphatase 169 IU / L, alanine aminotransferase 4421 IU / L, aspartate aminotransferase 1825 IU / L, γ glutamyl transpeptidase 275IU / L. Virological tests showed that,