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OBJECTIVE: To evaluate the effect of tamoxifen (TAM) combined with a somatostatin analogue,octretide (OCT) on advanced liver cancer and whether tamoxifen combined with OCT is superior toregular chemotherapeutic agents 5-Fu and mitomycin C (MMC).METHODS: Thirty-nine patients with inoperable liver cancer were randomly subdivided into TAM+OCTgroup (n=24) and regular chemotherapeutic group (n=15). They received treatment for three monthsrespectively. Blood cell count, liver function, immunologic function, blood α-FP was regularly measured.Liver lump and extrahepatic metastasis were examined by CT. The patients were followed up aftertreatment and conducted survival analysis.RESULTS: In the TAM+OCT group, complete response is 4 patients, partial response is 7 patients, nochange is 9 patients and progressive disease is 4 patients; blood level of ALT and AST had no noticeablechange, IgE and IgG increased (P<0.01), and α-FP lowered (P
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