~(99)Tc~m(Ⅴ)-DMSA显像诊断卵巢良恶性肿瘤的价值

• 作 者: 赵新明 王建方 徐芳 尹洁 魏兰秀 孙莉
• 机 构: 河北医科大学第四医院ＥＣＴ室
• 出 处: 中华核医学杂志
• 发表日期: 1999年02期
• 关键词: 良恶性肿瘤 卵巢肿瘤 Tc~m DMSA 放射性核素显像 假阳性 手术病理结果 成熟畸胎瘤 鉴别诊断 亲肿瘤显像剂

目的探讨９９Ｔｃｍ（Ⅴ）二巯基丁二酸钠（ＤＭＳＡ）显像鉴别诊断卵巢良恶性肿瘤的临床价值。方法对２４例临床疑卵巢肿瘤的患者进行９９Ｔｃｍ（Ⅴ）ＤＭＳＡ显像，并与手术病理结果进行对照。结果２４例卵巢肿瘤患者经病理证实卵巢恶性肿瘤１５例，良性肿瘤９例。１５例卵巢恶性肿瘤，９９Ｔｃｍ（Ⅴ）ＤＭＳＡ显像阳性１４例，假阴性１例；９例良性肿瘤，显像阴性７例，假阳性２例。９９Ｔｃｍ（Ⅴ）ＤＭＳＡ诊断卵巢恶性肿瘤的灵敏度为９３３３％，特异性为７７７８％，阳性预测值为８７５０％，阴性预测值为８７５０％，假阳性为１４２９％，假阴性为６６７％，准确性为８７５０％。结论９９Ｔｃｍ（Ⅴ）ＤＭＳＡ显像在鉴别卵巢良恶性肿瘤方面具有重要的临床价值。

Objective To investigate the clinical value of 99Tcm-D dimercaptosuccinate (DMSA) imaging in the differential diagnosis of benign and malignant ovarian tumors. Methods Twenty-four patients with clinically suspected ovarian tumors underwent 99Tcm  DMSA imaging and were compared with surgical pathology results. Results Twenty-four cases of ovarian tumors were pathologically confirmed 15 cases of ovarian malignant tumors and 9 cases of benign tumors. Among 15 cases of ovarian malignant tumors, 14 cases were positive for 99Tcm (Ⅴ )DMSA imaging and 1 case was false negative; 9 cases were benign, 7 were imaging negative and 2 were false positive. The sensitivity of 99Tcm (Ⅴ)  DMSA in diagnosis of ovarian cancer was 9333%, specificity was 7778%, positive predictive value was 8750%, negative predictive value was 8750%, false positive was 1429 %, False negative was 667%, accuracy was 8750%. Conclusion 99Tcm   DMSA imaging in the identification of benign and malignant tumors of ovary has important clinical value.