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应用免疫组织化学方法,分别对喉粘膜上皮良性及恶性病变中nm23-H_1;蛋白进行检测,探讨nm23-H_1蛋白的表达水平与喉癌的生长、发展的关系。结果表明nm23-H_1;蛋白阳性产物主要定位于细胞浆,4例正常喉粘膜及8例慢性非特异性炎症均为阳性(100％),10例不典型增生8例为阳性(80％)、42例喉鳞状细胞癌26例为阳性(61.9％)。在12例发生转移的SCC中4例为阳性(33.3％),在3O例未发生转移的SCC中,22例为阳性(73.3％)。结论:nm23-H_1蛋白在喉部良性、癌前及癌变组织中均有一定程度的表达,其表达与喉部转移倾向呈显著性负相关。因此,nm23-H_1在抑制喉癌发生转移中起着重要的作用,有可能成为评价喉部病人预后的一项指标。
Immunohistochemistry was used to detect the expression of nm23-H_1 protein in benign and malignant lesions of the laryngeal mucosa. The relationship between the expression of nm23-H_1 protein and the growth and development of laryngeal carcinoma was also investigated. The results showed that the positive product of nm23-H 1 protein mainly located in the cytoplasm, 4 cases of normal laryngeal mucosa and 8 cases of chronic non-specific inflammation were positive (100%), 10 cases of atypical hyperplasia were positive (80%), 42 Twenty-six cases of laryngeal squamous cell carcinoma were positive (61.9%). Four of the 12 SCC cases were positive (33.3%), of which 22 were positive (73.3%) in 30 cases of SCC without metastasis. CONCLUSION: The nm23-H_1 protein is expressed in benign, precancerous and cancerous tissues, and the expression of nm23-H_1 is negatively correlated with the tendency of laryngeal metastasis. Therefore, nm23-H_1 plays an important role in inhibiting the metastasis of laryngeal carcinoma and may be an index to evaluate the prognosis of laryngeal patients.