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作者采用微机化的智能仪记录及处理资料,研究了我校新合成药维纳利酮(又名OPC—8212)对14例犬心肌细胞内电位的影响。结果:静息电位(RP)、动作电位振幅(APA)和0期去极最大速度(V_(max))在维纳利酮作用前后均无显著差异,而动作电位全程(APT)、动作电位复极至1/3时程(APD1/3)及复极至2/3时程(APD 2/3)均有明显增加。平台期有所抬高。提示维纳利酮并不影响心肌细胞膜静息时的K~+通透性,也不影响快Na~+通道的激活和开放数目。而有可能增加Ca~(2+)通道的开放时间、增加Ca~(2+)内流;也可能同时具有减弱延迟外向钾电流(Ik)和内向整流钾电流(Ik_1)的作用。因此维纳利酮有可能成为一种很有希望的非甙、非儿茶酚胺类的新型正性肌力药物。
Using computerized intelligent instrument to record and process data, the author studied the influence of venlafaxine (aka OPC-8212), a new synthetic drug in our university, on the potential of cardiomyocytes in 14 dogs. Results: There was no significant difference in resting potential (RP), action potential amplitude (APA) and maximal depolarization velocity (V max) at 0 phase before and after the administration of venlafaxine. However, APT, Polarization to 1/3 of the duration (APD1 / 3) and repolarization to 2/3 duration (APD 2/3) were significantly increased. Platform has been raised. It suggested that vinorelone did not affect K ~ + permeability at resting myocardial cells, nor did it affect the number of Na ~ + channels activated and opened. But may increase Ca 2+ channel opening time and increase Ca 2+ influx. It may also reduce the effects of delayed outward potassium current (Ik) and inwardly rectified potassium current (Ik_1). Venenone is therefore likely to be a promising new inotropic drug for non-glycosidic, non-catecholamines.