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目的:分析低分子肝素钙联合氨溴索对喘息性支气管炎患者血清CRP、TNF-α的影响。方法:回顾性分析我院2011年3月—2013年4月期间收治的78例喘息性支气管炎患者的临床资料,将其平均分成对照组与治疗组,给予对照组采用常规抗感染与激素治疗,治疗组在对照组的基础上采用低分子肝素钙雾化吸入联合氨溴索静脉滴注、小青龙汤加减治疗,比较两组患者血清C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)及治疗效果。结果:治疗后两组患者血清CRP和TNF-α都有显著下降,但治疗组下降更明显,两组相比差异具有统计学意义(P<0.05)。治疗组和对照组患者的喘息缓解时间、喘鸣音消失时间、湿罗音消失时间、咳嗽消失时间比较,差异明显,具有统计学意义(P<0.05)。且治疗组的治疗总有效率为94.9%(37/39),对照组的治疗总有效率为79.5%(31/39),两组疗效相比差异明显,具有统计学意义(P<0.05)。结论:低分子肝素钙联合氨溴索治疗喘息性支气管炎患者,疗效显著,可有效调节患者血清CRP的表达,改善TNF-α对患者身体的不良影响,促进患者早日康复,值得临床推广应用。
Objective: To analyze the effect of low molecular weight heparin calcium combined with ambroxol on serum CRP and TNF-α in asthmatic bronchitis patients. Methods: The clinical data of 78 patients with asthmatic bronchitis treated in our hospital from March 2011 to April 2013 were retrospectively analyzed. The patients were divided equally into the control group and the treatment group, and the control group was given conventional anti-infective and hormone therapy , The treatment group on the basis of the control group with low molecular weight heparin calcium inhalation combined with ambroxol intravenous infusion, Xiao Qing Long Decoction treatment, comparing two groups of patients serum CRP, TNF- α) and therapeutic effect. Results: Serum CRP and TNF-αwere significantly decreased in both groups after treatment, but the treatment group decreased more obviously. There was significant difference between the two groups (P <0.05). There were significant differences between the treatment group and the control group in wheezing relief time, wheezing disappearance time, wet rales disappearance time and cough disappearing time (P <0.05). The total effective rate was 94.9% (37/39) in the treatment group and 79.5% (31/39) in the control group, with significant difference between the two groups (P <0.05) . Conclusion: Low molecular weight heparin combined with ambroxol treatment of patients with asthmatic bronchitis, significant effect, which can effectively regulate the expression of serum CRP, improve the adverse effects of TNF-α on the patient’s body and promote recovery of patients, worthy of clinical promotion and application.