论文部分内容阅读
目的评价局部进展期乳腺癌的两种不同方案的新辅助化疗的近期疗效及其毒性反应。方法从2001年1月～2004年1月应用CEF、NEF两种不同化疗方案对68例局部进展期乳腺癌进行新辅助化疗。所有患者完成2个周期的新辅助化疗后评价疗效及毒性反应。结果原发灶有效率CEF、NEF两组分别为47.2%(17/36)和71.9%(23/32);其中各有1例病理完全缓解者,两组均无进展者。腋窝淋巴结有效率CEF、NEF两组分别为63.9%(23/36)和87.5%(28/32);新辅助化疗后CEF组有11例(30.6%),NEF组有17例(53.1%)未触及肿大淋巴结。两组均未见IV度毒性反应,白细胞下降、脱发及胃肠道反应两组程度相似。NEF组出现特有的神经毒性和周围静脉炎。结论两种不同方案用于局部进展期乳腺癌的新辅助化疗均有较好的近期疗效,毒性反应均可耐受。与CEF组相比,NEF组原发灶和腋窝淋巴结疗效均优于CEF组,而且两组毒性反应相当。
Objective To evaluate the short-term efficacy and toxicity of neoadjuvant chemotherapy in two different regimens of locally advanced breast cancer. Methods From January 2001 to January 2004, 68 cases of locally advanced breast cancer were treated with neoadjuvant chemotherapy by two different chemotherapy regimens, CEF and NEF. All patients completed two cycles of neoadjuvant chemotherapy to evaluate efficacy and toxicity. Results The effective rate of the primary tumor was 47.2% (17/36) and 71.9% (23/32) in the CEF and NEF groups, respectively. There were 1 cases of pathological complete remission in each group and no progress in both groups. The effective rates of axillary lymph nodes in CEF and NEF groups were 63.9% (23/36) and 87.5% (28/32) in the two groups, 11 (30.6%) in the CEF group after neoadjuvant chemotherapy and 17 (53.1%) in the NEF group Did not touch the enlarged lymph nodes. IV toxicity was not seen in both groups, leukopenia, alopecia and gastrointestinal reactions were similar in both groups. NEF group appeared unique neurotoxicity and peripheral phlebitis. Conclusions Both neoadjuvant chemotherapy regimens with two different regimens for locally advanced breast cancer have good short-term curative effect and tolerability. Compared with CEF group, NEF group primary tumor and axillary lymph node curative effect than CEF group, and the two groups of toxic reactions.