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目的分析探讨重组人干扰素α-2b栓不同给药间隔治疗宫颈糜烂的有效性及安全性。方法采用前瞻性随机对照实验方法,将91例宫颈糜烂患者按照随机分组方式分为A组(n=45)和B组(n=46),A组患者用重组人干扰素α-2b栓10万U治疗,1次/d,月经干净后第3天开始,连续治疗20d为1个疗程,治疗2个疗程;B组患者用干扰素α-2b栓10万U治疗,隔日1次,月经干净后第3天开始,经期停用,连用2个月。对比两组的疗效、不良反应。结果 A组的治疗总有效率高于B组,差异有显著性(P<0.05);两组的不良反应发生率无显著性差异(P>0.05)。结论干扰素治疗宫颈糜烂效果明显,干扰素α-2b栓10万U每日一次的用药方式能够明显提高治愈率,且不增加不良反应发生率。
Objective To investigate the effectiveness and safety of recombinant human interferon α-2b suppositories for treating cervical erosion at different intervals. Methods 91 patients with cervical erosion were randomly divided into group A (n = 45) and group B (n = 46) by prospective randomized controlled trial. Patients in group A were treated with recombinant human interferon alpha 2b Million U treatment, 1 time / d, after menstruation clean 3 days, continuous treatment of 20d for a course of treatment for 2 courses; B group of patients with interferon α-2b suppositories 100,000 U treatment, every other day 1, menstrual After the first 3 days clean, menstrual disabled, once every 2 months. The curative effect and adverse reaction of two groups were compared. Results The total effective rate of treatment in group A was higher than that in group B (P <0.05). There was no significant difference in adverse reactions between two groups (P> 0.05). Conclusion Interferon is effective in treating cervical erosion. Interferon α-2b suppository with a dose of 100,000 U once a day can obviously improve the cure rate without increasing the incidence of adverse reactions.