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妊娠期间大部分自身免疫性肝炎(AIH)患者可以维持病情稳定甚至缓解,但分娩后容易出现复发,严重者可出现肝纤维化、甚至肝硬化、肝昏迷。AIH患者发生妊娠不良事件的概率增加,如早产、流产等。AIH患者妊娠期间遵循肝病医生的医嘱将泼尼松减至最小剂量继续维持治疗。妊娠的AIH患者需要在产科和肝病医生的共同监护下,在妊娠期及产后密切随访。
During pregnancy, most patients with autoimmune hepatitis (AIH) can maintain stable or even alleviate their symptoms, but relapse after delivery is more likely. In severe cases, liver fibrosis, cirrhosis and hepatic coma occur. AIH patients with increased probability of adverse pregnancy events, such as premature delivery, abortion and so on. AIH patients during pregnancy follow liver disease doctor’s advice will be reduced to the minimum dose of prednisone to continue treatment. Pregnant AIH patients need close follow-up during pregnancy and after childbirth under the co-supervision of obstetricians and hepatopathy practitioners.