论文部分内容阅读
本文报告一例慢性支气管哮喘因使用色甘酸钠引起严重支气管痉挛。患者男性,42岁,吸入色甘酸钠20毫克,每天4次,共12个月。临床症状有改善。改用皮质激素雾化剂治疗15个月,因哮喘复发,重新使用色甘酸钠。一个月后吸入此药即出现气短及喘息,乃改为口服强的松龙。以后用倍氯米松100微克,每天4次及强的松龙5毫克,每天一次作维持治疗。检查:血清免疫球蛋白E含量正常。色甘酸钠斑贴和皮内试验均阴性。吸入色甘酸钠5分钟,一秒最大呼气量(FEV_1)从治疗前的2.75升下降至0.7升,10分钟时达0.6升,有显著呼吸抑制,用间歇正压通气给予舒喘灵,情况立即改善,FEV_1增至2.75升。在吸入色甘酸钠前20分钟用间歇正压通气给予0.5％舒喘
This article reports a case of chronic bronchial asthma due to the use of cromolyn sodium causes severe bronchospasm. Male patient, 42 years old, inhaled cromolyn sodium 20 mg 4 times daily for 12 months. Clinical symptoms have improved. Use corticosteroid atomization therapy for 15 months, due to the recurrence of asthma, re-use cromolyn sodium. One month after inhalation of the drug appears shortness of breath and wheezing, is changed to oral prednisolone. After using beclometasone 100 micrograms, 4 times a day and prednisolone 5 mg, once a day for maintenance treatment. Check: serum immunoglobulin E content is normal. Sodium cromoglycate patch and intradermal test were negative. Inhaled cromolyn sodium 5 minutes, one second maximum expiratory volume (FEV_1) decreased from 2.75 liters before treatment to 0.7 liters, 0.6 liters at 10 minutes, significant respiratory depression, intermittent positive pressure to give cisplatin, the situation Immediately improved, FEV_1 increased to 2.75 liters. Twenty-five minutes prior to inhalation of cromolyn sodium with intermittent positive pressure ventilation given 0.5% of the asthma