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18-甲基炔诺酮是国内外广为应用的口服避孕药.D-18-甲基炔诺酮(1)可用光学活性中间体(3)合成,(3)则是从13-乙基开环甾体(2)经微生物的不对称还原获得.光学活性化合物(6)或(9)也是一个合成D-18-甲基炔诺酮(1)的中间体.(6)是由对称三酮(4)在手
18-norgestrel is widely used in domestic and foreign oral contraceptives.D-18-norgestrel (1) can be optically active intermediates (3) synthesis, (3) is from 13-ethyl The ring-opened steroid (2) is obtained by asymmetric reduction of microorganisms The optically active compound (6) or (9) is also an intermediate for the synthesis of D-18-norgestrel (1) Trione (4) in hand