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右美托咪定（ DEX）是高选择性α2肾上腺素能受体激动剂，具有镇静、抗焦虑、抗交感、减弱应激及镇痛等多重作用。 DEX的给药途径广泛，滴鼻应用无创、无鼻黏膜刺激，易被小儿和家长接受。 DEX滴鼻给药起效较快，作用平稳，对呼吸无影响，临床使用安全性高，广泛用于小儿的术前准备以及需要麻醉辅助的相关检查中，能有效减少患儿的焦虑、恐惧心理，减少麻醉药物及阿片类药物的用量，提高麻醉质量。“,”Dexmedetomidine(DEX) is a selective α2-adrenergic receptor agonist.It has the functions of sedative,analgesic,anxiolytic and inhibiting the excitability of sympathetic nerve .The intranasal administra-tion of DEX is easily accepted by children for the reason of noninvasive and non-nasal mucosa irritation.DEX has satisfactory effect on reducing anxiety and fear of children and also the dosage of narcotic drugs and opi-oids,thus is widely used in pediatric preoperative preparation and examination .