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Objective: To study temporal and spatial development of EEG patterns in sporad ic and iatrogenic Creutzfeldt Jakob disease patients. Methods: Temporal and spa tial development of EEG patterns in 4 patients with sporadic Creutzfeldt Jakob disease and 2 patients with iatrogenic Creutzfeldt Jakob disease due to implant ation of contaminated brain depth electrodes were investigated. A total of 56 EE Gs were analyzed, over time spans ranging from 1272 to 3 days prior to death. Re sults: Frontal intermittent rhythmical delta activity (FIRDA) was seen at early timepoints in 4/6 patients and might represent an early EEG pattern that is asso ciated, with human prion diseases. EEG patterns associated with CJD are sensitiv e to midazolam. Initial EEG changes were seen at the site of prion exposure in i atrogenic Creutzfeldt Jakob disease patients, before they could be observed at distant sites, suggesting that prion disease was initiated at the site of prion exposure. Conclusions: Serial EEG recordings are a valuable tool not only in the early diagnosis of sporadic CJD, but also in the determination of prion exposur e in iatrogenic Creutzfeldt Jakob disease. Significance: FIRDA occur at an earl y stage of CJD and are progressively replaced by the classical PSWC. The EEG pat terns of CJD are sensitive to midazolam. The initial EEG changes in iatrogenic C JD are seen at the site of prion exposure.
Methods: Temporal and spa development of EEG patterns in 4 patients with sporadic Creutzfeldt Jakob disease and 2 patients with iatrogenic Creutzfeldt Jakob disease due to implant A total of 56 EE Gs was analyzed, over time spans ranging from 1272 to 3 days prior to death. Re sults: Frontal intermittent rhythmical delta activity (FIRDA) was seen at early timepoints in 4 / 6 EEG patterns associated with CJD are sensitiv e to midazolam. Initial EEG changes were seen at the site of prion exposure in i atrogenic Creutzfeldt Jakob disease patients, before suggesting could prion disease was initiated at the site of prion exposure. Conclusions: Serial EEG reco rdings are a valuable tool not only in the early diagnosis of sporadic CJD, but also in the determination of prion exposur e in iatrogenic Creutzfeldt Jakob disease. Significance: FIRDA occurred at an earl y stage of CJD and are progressively replaced by the classical PSWC. The EEG pat terns of CJD are sensitive to midazolam. The initial EEG changes in iatrogenic C JD are seen at the site of prion exposure.