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目的探讨葡萄糖转运蛋白Ⅰ型(glucose transporter 1,GLUT1)和肿瘤增殖细胞核抗原Ki-67在卵巢上皮性肿瘤组织中的表达及其临床意义。方法收集2000年1月2008年6月不同卵巢上皮性肿瘤病变患者119例的组织标本,采用免疫组织化学SP二步法检测肿瘤组织中GLUT1和Ki-67的表达情况。结果卵巢交界性、恶性上皮性肿瘤灶性或广泛高表达GLUT1和Ki-67,其表达强度有差异。卵巢良性上皮性肿瘤不表达GLUT1和Ki-67。在卵巢癌中GLUT1及Ki-67的表达强度与病理分级、临床分期、预后有关。GLUT1表达强度与病理分型无关,Ki-67表达强度与病理分型有关。结论卵巢上皮性肿瘤组织中GLUT1和Ki-67的表达具有相关性,其表达强度与肿瘤的良恶性质和增殖状态有关,二者同时检测可以全面了解卵巢上皮性肿瘤的性质、卵巢癌恶性程度和生物学行为,对于判断肿瘤的性质和预后有一定价值。
Objective To investigate the expression of glucose transporter 1 (GLUT1) and tumor proliferating cell nuclear antigen Ki-67 in ovarian epithelial tumor and its clinical significance. Methods Totally 119 samples from 119 patients with epithelial ovarian tumor were collected from January 2000 to June 2008. The expression of GLUT1 and Ki-67 in tumor tissues were detected by immunohistochemical SP method. Results The expression of GLUT1 and Ki-67 in focal or malignant ovarian borderline or malignant epithelial tumors was highly expressed. Ovarian benign epithelial tumors do not express GLUT1 and Ki-67. The expression of GLUT1 and Ki-67 in ovarian cancer is related to the pathological grade, clinical stage and prognosis. The expression intensity of GLUT1 had no relation with the pathological type, and the expression intensity of Ki-67 correlated with the pathological type. Conclusions The expression of GLUT1 and Ki-67 in epithelial ovarian cancer is correlated with the expression of GLUT1 and Ki-67. The expression of GLUT1 and Ki-67 is correlated with the malignant and proliferative status of ovarian cancer. The simultaneous detection of GLUT1 and Ki-67 can fully understand the nature of epithelial ovarian cancer, And biological behavior, to determine the nature of the tumor and prognosis of a certain value.