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目的：观察双通道转换酶抑制剂福辛普利（ｆｏｓｉｎｏｐｒｉｌ）治疗原发性高血压的降压疗效及其对尿微量蛋白排泄的影响。方法：比较２４例高血压病Ⅱ期患者口服福辛普利（１０～２０ｍｇ／ｄ）４周前后血压、心率及２４ｈ尿微量蛋白的排泄，并比较了它们之间的相关关系。结果：服药后血压明显下降（Ｐ＜０．０５，Ｐ＜０．００１），尿微量蛋白排泄明显降低（Ｐ＜０．０５），两者无相关关系，降压总有效率为６３％，心率及内生肌酐清除率无明显变化。结论：福辛普利在对原发性高血压有明显的降压作用同时减少尿白蛋白排泄，对肾脏具有保护作用
Objective: To observe the antihypertensive effect of fosinopril, a dual-channel converting enzyme inhibitor, and its effect on urinary microalbuminuria. Methods: The blood pressure, heart rate and 24h urinary excretion of excreted fosinopril (10 ~ 20mg / d) in 24 patients with stage Ⅱ of hypertension were compared before and after 4 weeks. The correlation between them was compared. Results: The blood pressure decreased significantly (P <0.05, P <0.001) and the excretion of urinary microalbumin significantly decreased (P <0.05). There was no correlation between them. The total effective rate of antihypertensive treatment was 63% Heart rate and endogenous creatinine clearance rate no significant change. Conclusion: Fosinopril has a significant antihypertensive effect on essential hypertension while reducing urinary albumin excretion, which has a protective effect on the kidney