Flavonoids from Scutellaria baicalensis Georgi are effective to treat cerebral ischemia/reperfusion

• 作 者: Yazhen Shang Hong Zhang Jianjun Cheng Hong Miao Yongping Liu Kai Cao Hui Wang
• 机 构: Department of Pharmacology of Basic Medical School,Wuhan University,Hebei Province Key Laboratory of
• 出 处: Neural Regeneration Research
• 发表日期: 2013年06期
• 关键词: Scutellaria flavonoids superoxide dehydrogenase ATPase reticulum endoplasmic occ

Based on previous studies that have shown flavonoids from the stems and leaves of Scutellaria baicalensis Georgi are neuroprotective agents in a naturally senile,D-galactose,aging in vivo model,as well as an in vitro model of oxidative/hypoxic injury,we established a cerebral ischemia/reperfusion model in rats by middle cerebral artery occlusion.The light/electron microscopic observations found significant neuropathological changes including neuron loss or swelling and rough endoplasmic reticulum injury.Moreover,the activities of lactate dehydrogenase,Na+-K+-ATPase,Ca2+-ATPase and superoxide dismutase were significantly lowered,and the levels of malonaldehyde increased.In addition,the memory of rats worsened.However,treatment with flavonoids from Scutellaria baicalensis Georgi (35,70 and 140 mg/kg) for 13 days dramatically improved the above abnormal changes.These results suggest that the ability of flavonoids from Scutellaria baicalensis Georgi in attenuating cerebral functional and morphological consequences after cerebral ischemia/reperfusion may be beneficial for the treatment of ischemic brain disease.

Based on previous studies that have shown flavonoids from the stems and leaves of Scutellaria baicalensis Georgi are neuroprotective agents in a naturally senile, D-galactose, aging in vivo model, as well as an in vitro model of oxidative / hypoxic injury, we established a Cerebral ischemia / reperfusion model in rats by middle cerebral artery occlusion. The light / electron microscopic observations found significant neuropathological changes including neuron loss or swelling and rough endoplasmic reticulum injury. Moreover, the activities of lactate dehydrogenase, Na + -K + -ATPase, Ca2 + Treatment of flavonoids from Scutellaria baicalensis Georgi (35, 70 and 140 mg / kg) for 13 days dramatically improved the above abnormal changes.These results suggest that the ability of flavonoids from Scutellaria baicalensis Georgi in attenuating cerebral functional and m orphological consequences after cerebral ischemia / reperfusion may be beneficial for the treatment of ischemic brain disease.