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观察慢性乙型病毒性肝炎 (CHB)患者 ( 2 5例 )经α 干扰素 (IFN α)抗病毒治疗前后血清中细胞因子和受体水平的变化与乙肝病毒消长之间的关系。收集治疗前后血清标本ELISA法同步检测 ,根据治疗后乙肝病毒复制指标 (HBV DNA)阴转分应答组 ( 10例 )与无应答组 ( 15例 )进行统计学分析。治疗后两组血清中IL 6水平下降 ,尤其应答组下降明显 ;治疗后应答组IL 2水平明显升高 (P <0 .0 1) ,sIL 2R水平则明显下降 ;但治疗后两组TNF α均较治疗前下降 ,相反IL 8水平升高接近正常人水平 ;CHB患者体内存在免疫功能的失调 ,通过IFN α免疫调节 (IL 6、IL 2、sIL 2R)对病毒复制影响具有重要作用。但TNF α和IL 8表达与病毒复制消长无相关关系
To observe the relationship between the change of serum cytokines and receptor levels in patients with chronic hepatitis B (CHB) (25 patients) before and after IFNα antiviral therapy and the growth and decline of hepatitis B virus. Serum samples were collected before and after the treatment of ELISA detection of synchronous detection, according to the treatment of hepatitis B virus replication index (HBV DNA) negative response group (10 cases) and no response group (15 cases) for statistical analysis. After treatment, the level of IL-6 in the two groups decreased, especially in the response group. After treatment, the level of IL-2 in the response group was significantly increased (P <0. 01) and the level of sIL 2R was significantly decreased. However, Which were all lower than those before treatment. On the contrary, IL8 level increased to nearly normal level. In patients with CHB, immune dysfunction existed. The immunomodulatory effects of IFNα (IL 6, IL 2, sIL 2R) on the replication of virus were important. However, there was no correlation between the expression of TNFα and IL 8 and the growth of virus replication