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最近输注前列腺素E_1(PGE_1)0.03mg·kg~(-1)·min~(-1) 7天,可改善ARDS 患者的存活,但此肺血管扩张作用很少证明对气体交换有作用,故作者对6例继发于ARDS 肺动脉高压症患者给PGE_I,测定血气、血液动力学和通气/灌注比((?)A/(?)),以评价其血管扩张作用。患者6例(男4,女2)年龄31～79岁,临床和放射学符合ARDS 诊断标准,全部患者平均肺动脉压>20mmHg,皆以呼气末正压(PEEP)通气.用自动血气分析器测量动脉和混合的静脉血气,多惰性气体排除法测定(?)A/(?)分布,5例患者用PGE_1 0.04μg·kg~(-1)·min~(-1)输注,1例用0.02μg·kg~(-1)·min~(-1).
The recent infusion of prostaglandin E_1 (PGE_1) 0.03 mg · kg -1 · min -1 for 7 days can improve the survival of patients with ARDS, but this pulmonary vasodilator effect is seldom proved to have an effect on gas exchange, Therefore, the authors evaluated 6 cases of PGE_I secondary to ARDS pulmonary hypertension, blood gas, hemodynamics and ventilation / perfusion ratio (? A / (?)), To evaluate its vasodilator effect. Six patients (male 4 and female 2) aged 31 to 79 years old, clinical and radiological meet the ARDS diagnostic criteria, all patients with an average pulmonary pressure> 20mmHg, all with positive end expiratory pressure (PEEP) ventilation with automatic blood gas analyzer Arterial and mixed venous blood gases were measured and A / (?) Distribution was determined by multiple inert gas exclusion. Five patients were infused with PGE 1 0.04 μg · kg -1 -1 min -1, Use 0.02μg · kg -1 (-1) min -1.