Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells

• 作 者: Oleksandr H Minchenko Katsuya
• 机 构: DepartmentofMolecularBiologyPalladinInstituteofBiochemistry,DepartmentofInnovativeOncologyNationalCa
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2014年38期
• 关键词: 6-phosphofructo-2-kinase/fructose-2 6-bisphosphata 6-phosphofructo-2-kinase/fruc

Enzymes 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and-4(PFKFB-3 and PFKFB-4)play a significant role in the regulation of glycolysis in cancer cells as well as its proliferation and survival.The expression of these mRNAs is increased in malign