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1943年 Pearce 与 Digrad 第1次报告经组织学诊断的食管疱疹感染4例。其他学者在尸解材料中寻找这一未被发现的疾病,检查结果发生率约为0.8‰～5‰。作者报告1例,男,75岁。由于上消化道出血而作食管镜检,发现整个食管内衬以一层白色壁布样物。粘膜触之易损伤,部分糜烂。从该处取材作细胞学检查:除颗粒白细胞和正常的食管扁平上皮之外,有多核性细胞,其胞质嗜兰以至两染性,核呈气泡样。要注意与腺癌所致的细胞改变相鉴别。这种病毒性疾病极少被发现的原因在于:①疱疹性食管炎确是一种罕见病,作者在340例食管刷检中仅见3例(0.9％);②有目的的食管镜检少于胃镜检,因此无法掌握所有的这种细胞变化;③病毒所致的细胞改变仅短期存在,因此不能经常查到。
In 1943 Pearce and Digrad first report of histologically diagnosed esophageal herpes infection in 4 cases. Other scholars in the autopsy material to find this undiscovered disease, the test result rate of about 0.8 ‰ ~ 5 ‰. The authors report 1 case, male, 75 years old. Because of upper gastrointestinal bleeding for esophageal microscopy, found the entire esophagus lined with a layer of white wall cloth samples. Mucosal touch easily damaged, partial erosion. From there for cytology: in addition to the granular leukocytes and normal esophageal flat epithelium, the multinucleated cells, the cytoplasm of Cymbidium or even two dye, the nucleus was bubble-like. Should pay attention to and cell differentiation caused by adenocarcinoma phase identification. This viral disease is rarely found because: ① herpes esophagitis is indeed a rare disease, the author in 340 cases of esophageal brushing only 3 cases (0.9%); ② purposeful esophageal microscopy less than Gastroscopy, and therefore can not grasp all such changes in cells; 3 virus-induced cellular changes exist only for a short time, it can not be found frequently.