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Objective: To observe the efficacy and safety of electroacupuncture on oral oxycodonehydrochloride prolonged-release tablets related constipation in Qi (气) deficiency syndrome. Methods:A randomized control trial was conducted in 44 participants, who were divided into the treatment group (electroacupuncture group) and the control group (western medicine group). Two groups were treated by electroacupuncture at Zusanli (ST36), Tianshu (ST25), Zhigou (SJ6) and Shangjuxu (ST37) acupoints every day for 20 mins for 14 consecutive days and lactulose oral solution 30 ml every day for 14 consecutive days respectively. The constipation symptoms, traditional Chinese medicine (TCM) symptoms, quality of life, physical condition before and after the treatments were observed, and the safety indicators were monitored. Results: The treatment group was better than the control group in improving constipation symptom score, improving TCM symptom score and improving quality of life score, and the difference was statistically significant. There was no significant difference between the two groups in improving physical condition score. No acupuncture related adverse events were observed in the treatment group. Two patients in the control group withdrew from the study due to taking emergency defecation therapy and mild diarrhea respectively. Conclusion: Electroacupuncture is better than lactulose in the treatment of Qi deficiency constipation related to oxycodone hydrochloride prolonged-release tablets. It can significantly improve the symptoms of constipation, improve the symptoms of TCM, improve the quality of life. It is safe and effective.