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目的：探讨乳腺癌患者的ｐ糖蛋白表达与生存率、ｎｍ２３抑制癌转移基因与淋巴结转移之间的关系。方法：应用免疫组化Ｓ－Ｐ法，观察随访１０年以上的乳腺癌组织中ｐ糖蛋白和ｎｍ２３蛋白的表达。结果：ｐ糖蛋白和ｎｍ２３的阳性表达率分别为３６．５０％和９５．１２％。ｐ糖蛋白的阳性表达率仅与乳腺癌患者生存率有关（Ｐ＜０．０１），１０年以上较低，而与乳腺癌组织学分型，组织学分级，临床分期、淋巴结转移等无明显相关（Ｐ＞０．０５）。ｎｍ２３蛋白的阳性表达强度与乳腺癌腋窝淋巴结转移之间呈非常显著性负相关（Ｐ＜０．０１）。结论：乳腺癌组织ｐ糖蛋白和ｎｍ２３蛋白的检测对乳腺癌患者的预后判断及治疗方案的选择、淋巴结转移的预测均有积极的临床意义。
Objective: To investigate the relationship between p-glycoprotein expression and survival rate, nm23 inhibition of metastasis gene and lymph node metastasis in breast cancer patients. METHODS: Immunohistochemical S-P method was used to observe the expression of p-glycoprotein and nm23 protein in breast cancer tissues that were followed for more than 10 years. Results: The positive expression rates of p-glycoprotein and nm23 were 36.50% and 95.12%, respectively. The positive expression rate of p-glycoprotein was only related to the survival rate of breast cancer patients (P<0.01), and it was lower than 10 years, but it was not significantly related to histological type, histological grade, clinical stage, lymph node metastasis, etc. (P>0.05). The positive expression intensity of nm23 protein was significantly negatively correlated with axillary lymph node metastasis in breast cancer (P<0.01). Conclusion: The detection of breast cancer tissue p-glycoprotein and nm23 protein has positive clinical significance for the prognosis of breast cancer patients, the choice of treatment options and the prediction of lymph node metastasis.