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目的 :观察前房内注射去甲万古霉素对预防白内障超声乳化摘除术后感染性眼内炎的作用。方法 :回顾本院 1997年 1月以来所施行的 15 5 2 0眼白内障超声乳化摘除联合人工晶体植入术 ,其中术中未在前房注射去甲万古霉素者 832 2眼 ,术中前房内注射去甲万古霉素者 7198眼。注射药物的方法为在白内障超声乳化摘除联合人工晶体植入术毕向前房内注射盐酸去甲万古霉素 0 4～ 0 8mg。记录并比较两组病例感染性眼内炎的发生率。结果 :随访时间 0 5～ 32个月。未注射药物组共有 5例 ( 5眼 )发生感染性眼内炎 ( 0 0 6 % ) ,其中细菌性眼内炎 4眼( 0 0 5 % ) ,真菌性眼内炎 1眼 ;注射药物组尚未发现感染性眼内炎的病例。结论 :我们的资料提示白内障超声乳化摘除联合人工晶体植入术毕前房内注射去甲万古霉素有预防细菌性眼内炎的作用
Objective: To observe the effect of anterior chamber injection of norvancomycin on preventing endophthalmitis after phacoemulsification cataract extraction. Methods: A retrospective review of 15,520 phacoemulsification and intraocular lens implantation performed in our hospital since January 1997, including 832 2 patients who did not receive norvancomycin in the anterior chamber during the operation, In-room injection of vancomycin 7198 eyes. Injection of drugs in phacoemulsification cataract extraction combined with intraocular lens implantation to the anterior chamber injection of norvancomycin hydrochloride 0 4 ~ 0 8mg. Record and compare the incidence of infectious endophthalmitis in both groups. Results: The follow-up time ranged from 0 to 32 months. There were 5 cases (5 eyes) of infective endophthalmitis (0 0 6%) in the non-injected group, including 4 cases of bacterial endophthalmitis (0 0 5%) and 1 case of fungal endophthalmitis. Injecting drug group No cases of infectious endophthalmitis have been found yet. CONCLUSIONS: Our data suggest that intraocular injection of norvancomycin may prevent bacterial endophthalmitis before phacoemulsification and intraocular lens implantation