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本研究观察了闭合性创伤小鼠淋巴细胞膜流动性的变化及其与脂质过氧化作用的关系。结果显示，创伤后来源于脾脏、胸腺及肠系膜淋巴结的淋巴细胞膜流动性降低，淋巴组织中丙二醛（ＭＤＡ）含量增加，谷胱甘肽（ＧＳＨ）、谷胱甘肽过氧化物酶（ＧＳＨＰｘ）、超氧化物歧化酶（ＳＯＤ）及维生素Ｅ（ＶＥ）含量均明显降低。淋巴细胞膜流动性同各指标变化密切相关。创伤血清中ＭＤＡ、ＳＯＤ及ＶＥ含量也显示类似变化。ＶＥ和ＳＯＤ体内应用可明显降低创伤小鼠血清及淋巴组织中ＭＤＡ水平，并提高淋巴细胞膜的流动性。上述结果表明，创伤后脂质过氧化作用可能是淋巴细胞膜流动性降低的重要原因。
In this study, the changes of lymphocyte membrane fluidity and the relationship with lipid peroxidation in mice with occlusal trauma were observed. The results showed that after the trauma, the fluidity of lymphocytes from spleen, thymus and mesenteric lymph nodes decreased, the contents of malondialdehyde (MDA) and glutathione (GSH), glutathione peroxidase (GSHPx ), Superoxide dismutase (SOD) and vitamin E (VE) were significantly decreased. The fluidity of lymphocyte membrane is closely related to the change of each index. Trauma serum MDA, SOD and VE content also showed similar changes. In vivo application of VE and SOD can significantly reduce MDA levels in serum and lymphoid tissue of traumatized mice and increase the fluidity of lymphocyte membrane. The above results show that post-traumatic lipid peroxidation may be an important reason for the decrease of fluidity of lymphocyte membranes.