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最近,对阴道避孕药结合有效的杀精子剂这一发展又重视起来。据报道:许多药如表面活性剂,抗心律失常药,抗抑郁药和一些螯合剂均具有效的杀精子活性。在这些药中,去污剂如Nonoxynol-9的浓度为0.12mg/ml时,可影响精子的活动力。去污剂的杀精子作用是通过损伤精浆膜实现的。本文报道从无患子分离出的皂角甙的杀精子活性。本研究所采用的人体新鲜精液具有计数满意,前向活动力强,形态正常的特点。2ml精液与2ml无患子液(用盐水稀释,浓度分别为0.05%、0.1%、1.25%和5%)混合孵育1.5和10分钟。从同一标本中取2 ml精液仅与盐水孵育作为对照。然后在标
Recently, the development of vaginal contraceptives in combination with effective spermicides is even more important. It is reported that many drugs such as surfactants, antiarrhythmic drugs, antidepressants and some chelating agents have effective spermicidal activity. In these drugs, detergents such as Nonoxynol-9 at a concentration of 0.12 mg / ml can affect sperm motility. The spermicidal effect of the detergent is achieved by damaging the seminal plasma membrane. This article reports the spermicidal activity of saponin isolated from Sapindaceae. The fresh semen used in this study has the characteristics of counting satisfactory, strong forward movement and normal morphology. 2 ml of semen were mixed with 2 ml of Succulent (diluted in saline at concentrations of 0.05%, 0.1%, 1.25% and 5%, respectively) for 1.5 and 10 minutes. 2 ml of semen from the same specimen was incubated with saline only as a control. Then in the standard