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目的研究缬沙坦对大鼠急性心肌梗死(AMI)后左室重构及心功能的影响。方法将80只雌性SD大鼠AMI后6 h随机分为:梗死对照组(MI-C组,n=30)、缬沙坦治疗组(MI-V组,n=30)及假手术组(Sham组,n=20)。MI-C组及MI-V组结扎冠状动脉左室支建立AMI模型,Sham组只在相同部位穿线后不结扎。MI-V组:将缬沙坦20 mg/(kg.d)以生理盐水15 ml/kg溶解后灌胃,每日2次,共7 d;MI-V组和Sham组:均以等量生理盐水灌胃,每日2次,共7 d。分别于AMI后12 h、3 d及7 d,测定血流动力学,进行超声和形态学检查。结果与Sham组比较,MI-C组的左室收缩压(LVSP)、左室内压最大上升速率(+dp/dt)和左室内压最大下降速率(-dp/dt)显著降低(分别为P<0.05及P<0.01);左室舒张末压(LVEDP)显著增加(P<0.01);左室舒张末期容积(LVEDV)、短轴(D)、左室相对质量(LVWI)逐渐增加,至7 d时显著增加(P<0.05或P<0.01);长轴(L)、球形指数、短轴缩短率(FS)逐渐降低,至7 d时显著降低(P<0.05或P<0.01)。与MI-C组比较,MI-V组的LVSP、+dp/dt、-dp/dt显著回升(P<0.05或P<0.01),LVEDP显著下降(P<0.05或P<0.01),LVWI逐渐下降,至7 d时降低显著(P<0.05),梗死范围从3 d、7 d开始显著减小(P<0.05)。LVEDV、D、LVWI及梗死范围均下降,至7 d时显著降低(P<0.05或P<0.01),L、球形指数、FS逐渐升高,至7 d时显著上升(P<0.05或P<0.01)。结论缬沙坦能减轻心肌梗死后左室构型的改变,改善早期AMI后大鼠的心功能,抑制左室重构,改善左室的功能。
Objective To investigate the effects of valsartan on left ventricular remodeling and cardiac function after acute myocardial infarction (AMI) in rats. Methods 80 female SD rats were randomly divided into infarction control group (MI-C group, n = 30), valsartan treatment group (MI-V group, n = 30) and sham operation group Sham group, n = 20). AMI models were established in MI-C group and MI-V group by ligating left ventricular branches of coronary artery. Sham group was not ligated after threading the same site. MI-V group: valsartan 20 mg / (kg · d) was dissolved in normal saline 15 ml / kg, 2 times a day, a total of 7 d; MI-V group and Sham group: Saline gavage, 2 times a day, a total of 7 d. The hemodynamics were measured at 12 h, 3 d and 7 d after AMI, respectively. Ultrasound and morphologic examination were performed. Results LVSP, + dp / dt and -dp / dt in MI-C group were significantly lower than those in Sham group (P (LVEDP), short axis (D) and left ventricular mass (LVWI) increased gradually to the level of <0.05 and P <0.01, respectively; LVEDP increased significantly (P <0.05 or P <0.01). The long axis (L), spherical index and short axis shortening rate (FS) decreased significantly at 7 d (P <0.05 or P <0.01). Compared with MI-C group, LVSP, + dp / dt and -dp / dt of MI-V significantly increased (P <0.05 or P <0.01), LVEDP decreased significantly (P <0.05 or P <0.01) (P <0.05). The extent of infarction decreased significantly from 3 d and 7 d (P <0.05). LVEDV, D, LVWI and infarct size decreased significantly (P <0.05 or P <0.01) at 7 d, and L, spherical index and FS increased gradually (P <0.05 or P < 0.01). Conclusion Valsartan can relieve left ventricular structural changes after myocardial infarction, improve cardiac function after early AMI, inhibit left ventricular remodeling and improve left ventricular function.