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[摘要] 目的 分析咪达唑仑、地西泮联合苯巴比妥治疗小儿惊厥性癫痫持续状态的临床效果及安全性。 方法 选取2017年12月至2020年2月我院收治的小儿惊厥性癫痫持续状态患儿84例作为研究对象，按照抽签法分为研究组和对照组，每组各42例，研究组给予咪达唑仑联合苯巴比妥治疗，对照组给予地西泮联合苯巴比妥治疗，比较两组患儿临床治疗情况，统计不良反应，观察临床疗效。 结果 研究组的退热时间、惊厥消失时间、药物起效时间及住院时间明显短于对照组，差异有统计学意义（P<0.05）。研究组不良反应总发生率为16.67%，低于对照组的30.95%，差异有统计学意义（P<0.05）。研究组临床总有效率为92.86%，高于对照组的78.57%，差异有统计学意义（P<0.05）。 结论 咪达唑仑联合苯巴比妥用于小儿惊厥性癫痫持续状态的优势明显，不良反应少，安全性高，值得在临床治疗中推广。
[关键词] 小儿惊厥性癫痫持续状态;咪达唑仑;苯巴比妥;地西泮
[Abstract] Objective To analyze the clinical effect and safety of phenobarbital combined with midazolam or diazepam in the treatment of pediatric convulsive status epilepticus. Methods A total of 84 children with pediatric convulsive status epilepticus admitted to and treated in our hospital from December 2017 to February 2020 were included in this study and were divided into the control group（n=42） and the study group（n=42） according to random number table method. The study group was treated with midazolam combined with phenobarbital， while the control group was treated with diazepam combined with phenobarbital. The conditions of clinical treatment were compared between the two groups， the adverse reactions（ADRs） were counted， and the clinical efficacy was observed. Results The defervescence time， the convulsion disappearance time， the onset time of effectiveness of drugs and the hospital stay of the study group were significantly shorter than those of the control group， the differences were statistically significant（P
[关键词] 小儿惊厥性癫痫持续状态;咪达唑仑;苯巴比妥;地西泮
[Abstract] Objective To analyze the clinical effect and safety of phenobarbital combined with midazolam or diazepam in the treatment of pediatric convulsive status epilepticus. Methods A total of 84 children with pediatric convulsive status epilepticus admitted to and treated in our hospital from December 2017 to February 2020 were included in this study and were divided into the control group（n=42） and the study group（n=42） according to random number table method. The study group was treated with midazolam combined with phenobarbital， while the control group was treated with diazepam combined with phenobarbital. The conditions of clinical treatment were compared between the two groups， the adverse reactions（ADRs） were counted， and the clinical efficacy was observed. Results The defervescence time， the convulsion disappearance time， the onset time of effectiveness of drugs and the hospital stay of the study group were significantly shorter than those of the control group， the differences were statistically significant（P