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自1969～1975年,作者等用二性霉素B治疗过25例继发全身念珠菌病的烧伤病人。年龄:1～14岁;烧伤面积:20～90%;深度烧伤:22～90%。其中71年以前的10例中仅3例存活,71年以后的15例中14例存活。作者指出,用二性霉素B治疗全身念珠菌病,其存活率与开始用药的早晚和疗程有关。因为:(1) 全身念珠菌病多根据血培养阳性确诊,而念珠菌在培养基中生长较慢,有时又可被误认为污染;(2) 二性霉素B有高度毒性;(3) 念珠菌病不一定发展为严重的全身感染,此时可用一些相对无害的方法,诸如撤除静脉内插管,停用抗菌素等而得以控制。因而,往往相当晚才开始用药,而此时病人
From 1969 to 1975, the authors treated amphotericin B with 25 cases of burn patients with secondary systemic candidiasis. Age: 1 ~ 14 years old; burn area: 20 ~ 90%; deep burn: 22 ~ 90%. Of these, only 3 of 71 patients survived 71 years earlier, and 14 of 15 patients survived 71 years later. The authors note that treatment of systemic candidiasis with amphotericin B has been associated with the sooner or later initiation of medication and duration of treatment. Because: (1) systemic candidiasis and more blood culture positive diagnosis, and Candida grow slowly in the medium, and sometimes mistaken for pollution; (2) amphotericin B has a high degree of toxicity; (3) Candidiasis does not necessarily develop into a serious systemic infection, but can be controlled by relatively innocuous methods, such as removing an intravenous cannula, stopping an antibiotic, and the like. Therefore, often quite late to start medication, and patients at this time