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为研究双氟沙星(Difloxacin,DIF)在草鱼(Ctenopharynodon idellus)体内的药代动力学以及在各组织中的残留量,采用高效液相色谱法测定在15℃水温状态下单次给草鱼灌喂20 mg/kg剂量的双氟沙星后,得出双氟沙星在各组织以及血液中的药时曲线均都符合二室开放性模型,双氟沙星能够在草鱼体内快速吸收,并且血液及各组织中均有分布,双氟沙星在草鱼体内的药物动力学方程为C=5.056e–0.012t+19.041e–0.011t,其中双氟沙星在血液、肌肉、肝脏、肾脏中吸收半衰期(T1/2α)分别为0.176h、0.562h、4.562h和1.477h,消除半衰期分别为(T1/2β)69.492h、65.303h、218.412h和163.937h,总体消除率(CL)分别为0.495、11.181、10.789和7.102 L/(h·kg),药时曲线下面积(AUC)分别为81.550、1277.55、807.470和1432.150μg/(L·h)。根据相关规定肌肉中双氟沙星最大残留量300μg/kg为标准,建议休药期26d以上。
In order to study the pharmacokinetics of Difloxacin (DIF) in Ctenopharynodon idellus and its residual content in each tissue, After a dose of 20 mg / kg of dlloxacin was given, the pharmacokinetic profiles of both difloxacin in various tissues and blood were in line with the two-compartment open model, which allowed rapid absorption in the grass carp and Blood and each tissue are distributed, the pharmacokinetic equation of bifloxacin in the grass carp is C = 5.056e-0.012t + 19.041e-0.011t, of which, in the blood, muscle, liver, kidney The half-lives (T1 / 2α) were 0.176h, 0.562h, 4.562h and 1.477h respectively, and the elimination half-lives were (T1 / 2β) 69.492h, 65.303h, 218.412h and 163.937h respectively. The overall elimination rates (AUC) were 81.550, 1277.55, 807.470 and 1432.150μg / (L · h), respectively. According to the relevant provisions of the largest muscle residue of 300μg / kg of dioxin as the standard, recommended over 26d withdrawal period.