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目的:探讨肝细胞癌(HCC)患者经导管化疗栓塞(TACE)治疗后复发和生存相关的独立危险因素。方法:收集我院因HCC而接受TACE治疗的135例患者的临床资料,进行回顾性分析,与肿瘤复发和患者生存相关的危险因素采用Cox回归风险模型进行研究。结果:135例HCC患者中位生存时间为25个月(95%CI为18.816 8~32.757 5)。单因素和多因素Cox回归分析显示:Child P分级(校正RR=1.379,95%CI为1.033~1.841,P=0.029)、患有糖尿病和高血压(校正RR=1.621,95%CI为1.199~2.192,P=0.002)是患者生存的独立危险因素。另外,糖尿病和高血压的合并症(校正RR=1.775,95%CI为1.233~2.554,P=0.002)是肿瘤复发的唯一危险因素。结论:患有糖尿病和高血压是TACE治疗HCC患者生存和肿瘤复发的独立危险因素。
Objective: To investigate the independent risk factors of recurrence and survival in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Methods: The clinical data of 135 patients who underwent TACE for HCC in our hospital were retrospectively analyzed. The risk factors related to tumor recurrence and patient survival were studied by Cox regression risk model. Results: The median survival time in 135 patients with HCC was 25 months (95% CI 18.816 8 to 32.757 5). Univariate and multivariate Cox regression analysis showed that Child P classification (adjusted RR = 1.379, 95% CI 1.033-1.841, P = 0.029) had diabetes mellitus and hypertension (adjusted RR = 1.621, 95% CI 1.199 ~ 2.192, P = 0.002) was an independent risk factor for survival in patients. In addition, complications of diabetes and hypertension (adjusted RR = 1.775, 95% CI 1.233 to 2.554, P = 0.002) were the only risk factors for tumor recurrence. Conclusion: Diabetes mellitus and hypertension are independent risk factors for survival and tumor recurrence in patients with HCC.