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多年来对儿童尿道感染的短程疗法一直存在争议.作者对无并发症的尿道感染儿童进行了头孢呋辛酯(cefuroxime axetil)的两天疗法和常规的10天疗法的比较研究.年龄为2～10岁的50名儿童尿道感染患者,随机分组和对照.短程组为每日口服头孢呋辛酯125mg2次,治疗2天.另一组为10天.诊断尿道感染标准为在专门培养基中分离出单种病原菌为10~3cfu/ml以上,或者导尿管采取的尿标本病原菌为10~(?)cfu/ml以上.只要菌落绝对数在上述尿道感染阈值以下,停止药物治疗,3～5日后,分离的病原菌菌落数减少至1/10以下才确认达到细菌学治疗有效.患儿在治愈后随访15个月,进行放射摄影和多次反复的尿培养.短程组12例有8例达到细菌学治疗效果(67%),长程组14例有12例有效(86%),两组间无明显的差别,50例中有25例停止药物治疗,其中12例因开始时菌落计数不合适,从病儿的尿中分离尿道致病菌,所有37例患儿分离到的致病菌在体外对头孢呋辛酯都敏感.因此,头孢呋辛酯可以推荐为无并发症的儿科尿道感染的抗菌药物.虽然本研究的样本数不多,头孢呋辛酯两天疗法和10天疗法治疗尿道感染都有效.
There has been controversy over short years of treatment of urinary tract infections in children over the years. The authors compared the two-day treatment of cefuroxime axetil and conventional 10-day therapy in children with uncomplicated urinary tract infections, 50-year-old children with urinary tract infections were randomly divided into groups and controls.The short-term group was treated with 125 mg of cefuroxime axetil twice daily for 2 days and the other group was 10 days.The standard for diagnosis of urinary tract infection was isolation in specialized media A single pathogen is 10 ~ 3cfu / ml or more, or the urinary catheter pathogen taken by the catheter is 10 ~ (?) Cfu / ml or more. As long as the absolute number of colonies below the urinary tract infection threshold, stop the drug treatment, 3-5 In the future, the number of isolated pathogen colonies was reduced to less than 1/10 to confirm the effectiveness of bacteriological treatment.All children were followed up for 15 months after radiotherapy and repeated urinalysis in 12 cases of short-range group reached 8 Bacteriological treatment was effective (67%), while in the long-range group, 12 were effective (86%) in 14 and no significant difference between the two groups. Twenty-five of 50 discontinued drug treatment, of which 12 were unsuitable for initial colony counting , Isolated from the urine of sick children urinary tract pathogens, all 37 cases of children isolated from the pathogenic bacteria in vitro are sensitive to cefuroxime axetil.Therefore, cefuroxime axetil can be recommended as a complication of pediatric urinary tract infections of antimicrobial drugs.Although the sample number of this study, cephalosporins Furosemide two days therapy and 10 days treatment of urinary tract infections are effective.