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目的 观察原发性肾病综合征 (INS)患儿血甲状腺激素 (TH)水平与血白蛋白、尿蛋白的关系。方法 以放射免疫法检测 18例INS患儿和 18例正常儿 (对照组 )血总T3、T4 (TT3、TT4 )和游离T3、T4 (FT3、FT4 )水平 ,并测定 2 4h尿蛋白定量 (UPQ)及血白蛋白 (Salb)水平。结果 INS组血TT3、TT4 、FT3、FT4 水平分别为( 0 76± 0 2 2 )nmol/L、( 47 5 2± 18 2 8)nmol/L、( 2 2 8± 1 0 1) pmol/L、( 10 47± 3 92 )pmol/L ,与正常对照组比较差异显著 ;INS组血TT4 、FT3、FT4 与Salb水平呈正相关 ,与UPQ水平无相关性 ;血TT3 与Salb、UPQ水平无相关性。结论 INS患儿存在甲状腺功能低下 ,这一状态与血Salb水平降低有一定的关系。
Objective To observe the relationship between serum thyroid hormone (TH) and serum albumin and urine protein in children with primary nephrotic syndrome (INS). Methods The levels of total T3, T4 (TT3, TT4) and free T3, T4 (FT3, FT4) were measured by radioimmunoassay in 18 children with INS and 18 normal children (control group) UPQ) and serum albumin (Salb) levels. Results The levels of TT3, TT4, FT3 and FT4 in the blood of INS group were (0 76 ± 0 2 2) nmol / L, (47 52 ± 18 28) nmol / L and (2 2 8 ± 1 0 1) pmol / L, (10 47 ± 3 92) pmol / L, respectively. There was a significant positive correlation between serum TT4, FT3, FT4 and Salb level in INS group but no correlation with UPQ level Correlation. Conclusion There is hypothyroidism in children with INS, which is related to the decrease of blood Salb level.