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目的 研究心脏和肾脏短暂缺血预处理对急性心肌梗死(AMI)后心律失常的影响。方法 观察AMI组(A组)、心脏缺血预处理(MIP)组(B组)和肾脏缺血预处理(RIP)组(C组)新西兰兔在AMI前后的心律失常情况及QT间期离散度(QTd) ,并行心内电生理诱发室性心动过速(VT) ,对三组的指标进行比较,同时设置假手术组(D组)作对照。结果 四组在手术前心律失常及QTd差异无显著意义(P >0 . 0 5 ) ;D组手术前后心律失常及QTd比较差异无显著意义(P >0 . 0 5 ) ;在AMI后,B、C两组室性心律失常及QTd明显小于A组(P <0 . 0 5 ) ,而B、C两组室性心律失常及QTd比较差异无显著意义(P >0 .0 5 )。结论 MIP和RIP均可减少AMI后室性心律失常的发生,而且两者的作用没有明显差异。
Objective To investigate the effects of transient ischemic preconditioning of heart and kidney on arrhythmia after acute myocardial infarction (AMI). Methods Arrhythmia and QT interval discrepancy were observed in AMI group, MIP group, and RIP group (C group) before and after AMI (QTd), and cardiac electrophysiological-induced ventricular tachycardia (VT) were compared. The indexes of the three groups were compared, and the sham operation group (D group) was set as the control. Results There was no significant difference in arrhythmia and QTd between the four groups before operation (P> 0.05). There was no significant difference in arrhythmia and QTd between before and after operation in group D (P> 0.05). After AMI, B , Ventricular arrhythmia and QTd in group C were significantly lower than those in group A (P <0.05). There was no significant difference in ventricular arrhythmia and QTd between groups B and C (P> 0.05). Conclusions Both MIP and RIP can reduce the incidence of ventricular arrhythmias after AMI, and there is no significant difference between them.