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本文研究了青海省２８个疫源县（市）镇，不同宿主分离的鼠疫菌６９０株，根据生化性状，毒力因子、毒力、大质粒分子量差异、营养型等结合地理分布可分为三个生物型：即青藏高原型、祁连山型和阿尔金山型。其中青藏高原型又根据大质粒的分布分为两个亚型。各生物型有特定的分布区域，由于主要宿主相同，各生物型之间有近缘关系。揭示了青海疫源地内鼠疫病原体生物群落结构的复杂性，遗传变异的规律性及其流行病学意义。研究表明青海各生物型菌株对人和动物的侵袭力和毒力最强，在疫源地内必须加强综合性防治措施，以控制动物鼠疫流行并严防波及人间。本研究还首次提出了以大质粒分子量差异作为本疫源地内区分鼠疫菌生物亚型的指标。
In this paper, 690 strains of Yersinia pestis isolated from different host counties in 28 epidemic counties (cities) of Qinghai Province were classified into three types according to the geographical distribution of biochemical traits, virulence factors, virulence, large molecular weight differences, A biological type: the Qinghai-Tibet Plateau, Qilian Mountains and Altun Mountains. Among them, the Qinghai-Tibet Plateau is divided into two subtypes according to the distribution of large plasmids. Each biotype has a specific distribution area, due to the same main host, there is a close relationship between the various biotypes. Revealed the complexity of the plague pathogens in Qinghai Province, the regularity of genetic variation and its epidemiological significance. Studies have shown that all strains of Qinghai have the strongest invasiveness and virulence to humans and animals. Comprehensive prevention and control measures must be strengthened in foci so as to control the spread of animal plague and prevent it from affecting the human beings. This study also proposed for the first time the difference in the molecular weight of large plasmids as an indicator of the differentiation of the Yersinia pestis subtype within the source of this disease.