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目的分析原发性中枢神经系统淋巴瘤的综合治疗方法和预后。方法确诊原发性中枢神经系统淋巴瘤患者39例,根据术后复查头颅CT或MR结果分为手术全切组(15例)和未全切组(24例),术后均给予同步放、化疗。治疗前后均对患者进行卡氏评分(KPS)并随访生存时间。结果全切组与未全切组在疾病的缓解程度上无统计学差异。KPS≥70分者的中位生存时间提高(P<0.05)。结论对原发性中枢神经系统淋巴瘤患者,需采用手术、放疗、化疗为主的综合治疗。手术全切病灶与否对预后无明显影响;KPS是预示患者生存期的一个重要指标。
Objective To analyze the comprehensive treatment and prognosis of primary central nervous system lymphoma. Methods Thirty-nine patients with primary central nervous system lymphoma were identified. According to the postoperative CT or MR findings, the patients were divided into two groups: complete operation group (15 cases) and incomplete partial group (24 cases) Chemotherapy. Patients before and after treatment were Kappa score (KPS) and follow-up survival time. Results There was no significant difference in the degree of disease relief between the resection group and the resection group. The median survival time in KPS ≥70 improved (P <0.05). Conclusion For patients with primary central nervous system lymphoma, surgery, radiotherapy and chemotherapy should be used. Surgical resection of the lesion has no significant effect on prognosis; KPS is an important indicator of survival of patients.