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为避免肝脏对药物的首过作用,经皮肤应用硝酸甘油是一种有效的给药方法,但有些人的皮肤对药物的穿透性极低,使应用该系统给药明显受到影响.解决这个问题的方法之一是在给药系统中加入助渗剂,以增进硝酸甘油穿透皮肤的能力.本文报道了应用不同溶媒添加剂(即助渗剂)对硝酸甘油穿透裸鼠皮肤的体外实验结果.实验用溶媒有PG(丙二醇);OA(油酸),DMSO(二甲亚砜),DPT(1,3-二甲基-3,4,5,6-四氢-2(1H)-嘧啶酮;EHD(2-乙基-1,
In order to avoid the first pass of liver drugs, transdermal application of nitroglycerin is an effective method of administration, but some people’s skin permeability of the drug is very low, so that the application of the system administration was significantly affected. One of the problems is to add penetration enhancers to the delivery system to enhance the ability of nitroglycerin to penetrate the skin.In this paper, we report the in vitro experiments of nitroglycerin penetrating the skin of nude mice using different vehicle additives Results Experimental solvents were PG (propylene glycol); OA (oleic acid), DMSO (dimethylsulfoxide), DPT (1,3-dimethyl-3,4,5,6-tetrahydro- -pyrimidinone; EHD (2-ethyl-1,