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很早就有报告,梗阻性黄疸病人血浆总胆固醇含量增高,而肝细胞实质性病变时血浆胆固醇含量则可下降。近10年来,这一方面的研究进展较快。大量资料表明,肝脏在脂质和脂蛋白代谢中具有十分重要的作用。临床中见到的许多血浆脂质和脂蛋白异常情况,事实上都直接或间接地与肝脏代谢相联系;另一方面,许多肝脏疾患也可引起脂蛋白量和质的改变。了解这些变化,可能有助于本病的临床诊断、预后判断和防治措施的制订关于血浆脂蛋白的一些新认识血浆中主要的脂蛋白脂蛋白是由特异的蛋白质(即载脂蛋白,Apolipoprotein,以下称Apo)和脂质(包括胆固醇、胆固醇酯、甘油三酯和磷脂等)组成的生
It has been reported for a long time that patients with obstructive jaundice had elevated plasma total cholesterol levels and plasma cholesterol levels decreased during substantial liver cell damage. In the past 10 years, the research in this field has progressed rapidly. Numerous data show that the liver plays a very important role in lipid and lipoprotein metabolism. Many of the abnormalities in plasma lipids and lipoproteins seen in clinical practice are, in fact, directly or indirectly linked to liver metabolism; on the other hand, many liver disorders can also cause changes in the amount and quality of lipoproteins. Understanding these changes may contribute to the clinical diagnosis of the disease, prognosis and prevention and control measures on the development of some new understanding of plasma lipoprotein The main lipoproteins in plasma lipoproteins are composed of specific proteins (Apolipoprotein, Apolipoprotein, Hereinafter referred to as Apo) and lipids (including cholesterol, cholesterol esters, triglycerides and phospholipids, etc.)