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内皮素-1(ET-1)是最近发现的一种由内皮细胞产生的肽,可能是已被证实的最有效的血管收缩肽。脑微血管产生 ET-1,并对其有很高的敏感性。在 SAH 病人的脑脊液中 ET-1浓度升高,说明 ET-1在脑血管痉挛发生中起着作用。ET-3的结构和功能与 ET-1相似,神经组织也能产生 ET-3。理论上讲,急性脑缺血时,受损的内皮和神经细胞产生ET-1 和 ET-3过量,导致局部血管强烈、持久地收缩,对急性脑组织损伤的致病和预后起作用。作者对16名经临床和 CT 确诊为急性缺血性卒中发病后72h 连续入院的病人用放免法测定血浆 ET-1和ET-3浓度。另有13例年龄相匹配的非脑缺血病人
Endothelin-1 (ET-1), a recently discovered peptide produced by endothelial cells, may be the most potent vasoconstrictor peptide that has been demonstrated. Cerebral capillaries produce ET-1 and are highly sensitive to it. Elevated concentrations of ET-1 in cerebrospinal fluid of SAH patients suggest that ET-1 plays a role in the development of cerebral vasospasm. The structure and function of ET-3 is similar to that of ET-1, which also produces ET-3. In theory, excessive ET-1 and ET-3 are produced in impaired endothelial and nerve cells during acute cerebral ischemia, resulting in intense, permanent contraction of local blood vessels and contributing to the pathogenesis and prognosis of acute brain injury. The authors tested the plasma levels of ET-1 and ET-3 by radioimmunoassay in 16 consecutive patients hospitalized 72 h after clinical and CT-confirmed acute ischemic stroke. Another 13 age-matched non-ischemic patients