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目的研究新生儿肺泡表面活性物质的最佳给药方式。方法将96例呼吸窘迫综合征新生儿,采用肺泡表面活性物质进行治疗,随机分为观察组和对照组,各48例。观察组患儿使用三通连接气管插管与复苏气囊,经三通侧孔注入全部药液。对照组使用注射器连接,同时去掉针头的头皮针软管,把软管插到气管插管头端,分多次注入药物后抽出软管,再使用复苏气囊,将气管插管实施正压通气l~2 min后,经过多次滴注全部药液。结果观察组Sp O2在用药前后差异无统计学意义。操作时间和药物反流:观察组和对照组比较,差异有统计学意义(P<0.05)。结论采用三通连接气管插管以及复苏气囊的方法,经过三通侧孔滴注到注入肺表面活性物质给药不良反应比较少,并且减少了药物浪费,操作方法简单,值得大范围推广。
Objective To study the optimal administration of alveolar surfactant in neonates. Methods A total of 96 newborn infants with respiratory distress syndrome were treated with alveolar surfactant and randomly divided into observation group and control group, with 48 cases in each group. Observation group children use tee to connect tracheal intubation and resuscitation balloon, all through the three side holes into the liquid medicine. The control group using a syringe connection, while removing the needles of the scalp needle hose, the hose inserted into the end of the tracheal intubation, after multiple injections of drugs out of the hose, and then use the recovery balloon, the tracheal intubation positive pressure ventilation l ~ 2 min, after a number of instillation of all liquid. Results The observation group Sp O2 in the medication before and after the difference was not statistically significant. Operation time and drug reflux: the observation group and the control group, the difference was statistically significant (P <0.05). CONCLUSION: The tee method of tracheal intubation and balloon resuscitation is adopted. The side effects of three-way side-hole infusion into pulmonary surfactant are less adverse drug reactions, and the waste of drugs is reduced. The operation method is simple and worthy of wide application.